3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

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Chemical Name:3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate
CAS No.:1449521-92-9
Molecular Formula:C₃₉H₅₇NO₉Si₂
Molecular Weight:740.054
Hs Code.:

3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

Synonyms:3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

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Chemical Property of 3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

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Technology Process of 3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

There total 7 articles about 3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₅₉NO₁₀Si₂

: 1449521-92-9
3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

Guidance literature:: In methanol; dichloromethane; isopropyl alcohol; at 110 ℃; for 2.5h; Sealed tube; Molecular sieve;
DOI:10.1016/j.tetlet.2013.05.044

Reference yield:

: 1449521-91-8
3-(tert-butyldimethylsilyloxy)-3-(4-(tert-butyldimethylsilyloxy) phenyl)-N-methoxy-N-methylpropanamide

: 1449521-92-9
3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 0.33 h / -78 °C

1.3: 2 h / -25 - -5 °C

2.1: toluene / 1 h / Reflux

3.1: dichloromethane; methanol; isopropyl alcohol / 2.5 h / 110 °C / Sealed tube; Molecular sieve

With lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1016/j.tetlet.2013.05.044

Reference yield:

: C₂₃H₄₂O₄Si₂

: 1449521-92-9
3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.42 h / -40 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 0.33 h / -78 °C

2.3: 2 h / -25 - -5 °C

3.1: toluene / 1 h / Reflux

4.1: dichloromethane; methanol; isopropyl alcohol / 2.5 h / 110 °C / Sealed tube; Molecular sieve

With isopropylmagnesium chloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1016/j.tetlet.2013.05.044