3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol

Base Information

• Chemical Name: 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol
• CAS No.: 65487-77-6
• Molecular Formula: C₁₅H₁₃Br₃O₅
• Molecular Weight: 512.977
• Mol file: 65487-77-6.mol

Synonyms:3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol

Chemical Property of 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol

There total 6 articles about 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy-6′-hydroxymethyldiphenylmethane → 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol (65487-77-6)

Guidance literature:

In dichloromethane; at 0 - 60 ℃; for 3.16667h; Inert atmosphere;

DOI:10.1002/hlca.200900300

Reference yield:

{3-bromo-2-[(2,3-dibromo-4,5-dimethoxyphenyl)methyl]-4,5-dimethoxyphenyl}methanol (1238891-85-4) → 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol (65487-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C

2: phosphoric acid / 2 h / Reflux

With phosphoric acid; boron tribromide; In dichloromethane;

DOI:10.1016/j.ejmech.2013.03.037

Reference yield:

3-bromo-4,5-dimethoxy-toluene (68278-85-3) → 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl]methyl-5-(methoxymethyl)-1,2-benzenediol (65487-77-6)

Guidance literature:

Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 0.5 h / Irradiation

3: potassium carbonate; water / 1,4-dioxane / 3 h / Reflux

4: boron tribromide / dichloromethane / 4 h / 0 - 20 °C

5: phosphoric acid / 2 h / Reflux

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phosphoric acid; water; boron tribromide; potassium carbonate; In 1,4-dioxane; tetrachloromethane; dichloromethane; 1: |Friedel-Crafts Alkylation;

DOI:10.1016/j.ejmech.2013.03.037

upstream raw materials:

methanol

{3-bromo-2-[(2,3-dibromo-4,5-dimethoxyphenyl)methyl]-4,5-dimethoxyphenyl}methanol

3-bromo-4,5-dimethoxy-toluene

(2,3-dibromo-4,5-dimethoxyphenyl)methanol

Downstream raw materials:

2,3-dibromo-1-[2-bromo-3,4-dimethoxy-6-(methoxymethyl)benzyl]-4,5-dimethoxybenzene