N₁,N₂-bis(benzyloxycarbonyl)-N₁-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine

Base Information

• Chemical Name: N₁,N₂-bis(benzyloxycarbonyl)-N₁-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine
• CAS No.: 1555938-56-1
• Molecular Formula: C₂₇H₃₂N₄O₅
• Molecular Weight: 492.575

Synonyms:N₁,N₂-bis(benzyloxycarbonyl)-N₁-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine

Chemical Property of N₁,N₂-bis(benzyloxycarbonyl)-N₁-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine

Chemical Property:

Purity/Quality:

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Technology Process of N₁,N₂-bis(benzyloxycarbonyl)-N₁-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine

There total 4 articles about N₁,N₂-bis(benzyloxycarbonyl)-N₁-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-{5-[(dimethylamino)methyl]furan-2-yl}propan-1-ol (1194676-57-7) + N1,N2-bis(benzyloxycarbonyl)guanidine (10065-79-9) → N1,N2-bis(benzyloxycarbonyl)-N1-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine (1555938-56-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1039/c3md00245d

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N1,N2-bis(benzyloxycarbonyl)-N1-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine (1555938-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane; water / 20 h / 0 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/c3md00245d

Reference yield:

methyl 3-(2-furyl)propionate (37493-31-5) → N1,N2-bis(benzyloxycarbonyl)-N1-(3-{5-[(dimethylamino)methyl]furan-2-yl}propyl)guanidine (1555938-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C

2: ethanol / Reflux

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol;

DOI:10.1039/c3md00245d

upstream raw materials:

methyl 3-(2-furyl)propionate

3-furan-2-yl-propan-1-ol

benzyl chloroformate

3-{5-[(dimethylamino)methyl]furan-2-yl}propan-1-ol

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