ethyl 2-O-BOC-6-methylsalicylate

Base Information

Chemical Name:ethyl 2-O-BOC-6-methylsalicylate
CAS No.:252567-48-9
Molecular Formula:C₁₅H₂₀O₅
Molecular Weight:280.321
Hs Code.:

Synonyms:ethyl 2-O-BOC-6-methylsalicylate

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Chemical Property of ethyl 2-O-BOC-6-methylsalicylate

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Technology Process of ethyl 2-O-BOC-6-methylsalicylate

There total 1 articles about ethyl 2-O-BOC-6-methylsalicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 6555-40-4
ethyl 2-hydroxy-6-methylbenzoate

: 252567-48-9
ethyl 2-O-BOC-6-methylsalicylate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/np990241o

Reference yield: 68.0%

: 252567-48-9
ethyl 2-O-BOC-6-methylsalicylate

: 74-88-4
methyl iodide

: 252567-49-0
ethyl 2-O-BOC-6-ethylsalicylate

Guidance literature:: ethyl 2-O-BOC-6-methylsalicylate; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; N-benzylbenzamide; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/np990241o

Reference yield:

: 252567-48-9
ethyl 2-O-BOC-6-methylsalicylate

: 82064-77-5
2-ethyl-6-hydroxybenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; TMEDA; diisopropylamine; N-benzylbenzamide / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: 68 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 92 percent / HCO₂H / 4 h / 5 °C

With n-butyllithium; formic acid; N,N,N,N,-tetramethylethylenediamine; N-benzylbenzamide; diisopropylamine; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: Methylation / 2.1: Substitution;
DOI:10.1021/np990241o