4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

Base Information

Chemical Name:4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline
CAS No.:198961-85-2
Molecular Formula:C₂₀H₁₇BrN₆O₃
Molecular Weight:469.297
Hs Code.:

Synonyms:4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

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Chemical Property of 4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

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Technology Process of 4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

There total 1 articles about 4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 51390-23-9
1-(3-hydroxypropyl)imidazole

: 174709-17-2
4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline

: 198961-85-2
4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

Guidance literature:: 1-(3-hydroxypropyl)imidazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;

4-[(3-bromophenyl)amino]-7-fluoro-6-nitro-quinazoline; In tetrahydrofuran; for 24h; Further stages.; Heating;
DOI:10.1021/jm990482t

Reference yield: 82.0%

: 198961-85-2
4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

: 198961-86-3
6-amino-4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]quinazoline

Guidance literature:: With iron; acetic acid; In ethanol; for 0.333333h; Heating;
DOI:10.1021/jm990482t

Reference yield:

: 198961-85-2
4-[N-(3-bromophenyl)amino]-7-[3-(1H-imidazol-1-yl)propoxy]-6-nitroquinazoline

: N-[4-[(3-bromophenyl)-amino]-7-[3-(1,N-imidazyl)-propoxy]-quinazolin-6-yl]-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Fe; aq. HOAc / ethanol / 0.33 h / Heating

2: 2 percent / EDCI*HCl; pyridine / N,N-dimethyl-acetamide / 2 h / 20 °C

With pyridine; iron; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl acetamide; 1: Reduction / 2: Acylation;
DOI:10.1021/jm990482t