N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide

Base Information

• Chemical Name: N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide
• CAS No.: 1012054-73-7
• Molecular Formula: C₂₀H₁₉ClFN₅O₄
• Molecular Weight: 447.853

Synonyms:N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide

Chemical Property of N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide

Chemical Property:

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Technology Process of N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide

There total 9 articles about N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)propanoate (1146957-64-3) → N1-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N5-hydroxyglutaramide (1012054-73-7)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 0 - 20 ℃; for 0.666667h;

Reference yield:

4-chloro-7-methoxy-6-nitroquinazoline (55496-69-0) → N1-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N5-hydroxyglutaramide (1012054-73-7)

Guidance literature:

Multi-step reaction with 4 steps

1: isopropyl alcohol / 3 h / Heating / reflux

2: hydrogenchloride; water; iron / ethanol / 1 h / Heating / reflux

3: triethylamine / dichloromethane / 1.33 h / 0 - 20 °C

4: hydroxylamine / methanol / 0.17 h / 0 - 20 °C

With hydrogenchloride; water; hydroxylamine; iron; triethylamine; In methanol; ethanol; dichloromethane; isopropyl alcohol;

Reference yield:

7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2) → N1-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N5-hydroxyglutaramide (1012054-73-7)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium / 20 h / 100 °C

2: trichlorophosphate / 4 h / Heating / reflux

3: isopropyl alcohol / 3 h / Heating / reflux

4: hydrogenchloride; water; iron / ethanol / 1 h / Heating / reflux

5: triethylamine / dichloromethane / 1.33 h / 0 - 20 °C

6: hydroxylamine / methanol / 0.17 h / 0 - 20 °C

With hydrogenchloride; water; hydroxylamine; sodium; iron; triethylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; isopropyl alcohol;

upstream raw materials:

methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)butanoate

Methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)propanoate

7-chloro-3,4-dihydroquinazolin-4-one

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine hydrochloride

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