2-methylthio-5-trimethylstannylpyrimidine

Base Information

• Chemical Name: 2-methylthio-5-trimethylstannylpyrimidine
• CAS No.: 122476-79-3
• Molecular Formula: C₈H₁₄N₂SSn
• Molecular Weight: 288.989
• Mol file: 122476-79-3.mol

Synonyms:2-methylthio-5-trimethylstannylpyrimidine

Chemical Property of 2-methylthio-5-trimethylstannylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methylthio-5-trimethylstannylpyrimidine

There total 1 articles about 2-methylthio-5-trimethylstannylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-2-methylthiopyrimidine (14001-67-3) + trimethyltin(IV)chloride (1066-45-1) → 2-(methylsulfanyl)pyrimidine (823-09-6) + dimethylbis-(2-methylthiopyrimidin-5-yl)tin (122476-81-7) + 2-methylthio-5-trimethylstannylpyrimidine (122476-79-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; Addn. of butyl-lithium in hexane to a stirred soln. of CH3SC4H2N2Br in THF under N2 at -95°C followed by stirring for 60 min at -85°C, addn. of (CH3)3SnCl at -90°C, stirring for 30 min at -85°C and 20 h at 0°C.; Pouring into aq. ammonium chloride, stirring 10 min, sepn. of two phases, extn. of aq. phase with chloroform, washing the org. phases, drying (MgSO4), evapn., flash chromy. (silica gel; light petroleum-EtOAc), elem. anal.;

Reference yield: 97.0%

2-methylthio-5-trimethylstannylpyrimidine (122476-79-3) → 5-benzoyl-2-methylthiopyrimidine (110099-97-3)

Guidance literature:

With benzoyl chloride; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; Heating under reflux.; Evapn., recrystn. from methanol.;

Reference yield: 97.0%

2-methylthio-5-trimethylstannylpyrimidine (122476-79-3) + benzoyl chloride (98-88-4) → 5-benzoyl-2-methylthiopyrimidine (110099-97-3)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; for 4h; Heating;

upstream raw materials:

5-bromo-2-methylthiopyrimidine

trimethyltin(IV)chloride

Downstream raw materials:

5-benzoyl-2-methylthiopyrimidine

1-(2-(methylthio)pyrimidin-5-yl)ethanone