8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Base Information

Chemical Name:8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol
CAS No.:1356187-61-5
Molecular Formula:C₂₂H₂₅ClO₄S
Molecular Weight:420.957
Hs Code.:

Synonyms:8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

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Chemical Property of 8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

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Technology Process of 8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

There total 2 articles about 8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 26910-46-3
(chloro)(phenyl)methyl p-tolyl sulfoxide

: 1356187-61-5
8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: (chloro)(phenyl)methyl p-tolyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; Inert atmosphere; Cooling;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; Inert atmosphere; Cooling;
DOI:10.1055/s-0031-1260251

Reference yield:

: 10381-70-1,304690-05-9
benzyl 4-methylphenyl sulfoxide

: 1356187-61-5
8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / tetrachloromethane / 15 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling

2.2: Inert atmosphere; Cooling

With N-chloro-succinimide; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1055/s-0031-1260251

Reference yield: 91.0%

: 1356187-61-5
8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol

: 1356187-80-8
9-phenyl-1,4-dioxaspiro[4.6]undecan-8-one

Guidance literature:: 8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol; With tert-butylmagnesium chloride; In tetrahydrofuran; at -45 ℃; Inert atmosphere;

With isopropylmagnesium chloride; In tetrahydrofuran; at -45 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0031-1260251