26910-46-3

Basic information

• Product Name: (chloro)(phenyl)methyl p-tolyl sulfoxide
• Synonyms: (chloro)(phenyl)methyl p-tolyl sulfoxide
• CAS NO: 26910-46-3
• Molecular Weight: 264.776
• Mol File: 26910-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (chloro)(phenyl)methyl p-tolyl sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: (chloro)(phenyl)methyl p-tolyl sulfoxide(26910-46-3)
• EPA Substance Registry System: (chloro)(phenyl)methyl p-tolyl sulfoxide(26910-46-3)

Safety Data

• Hazardous Substances Data: 26910-46-3(Hazardous Substances Data)

Upstream product

• 10381-70-1 benzyl 4-methylphenyl sulfoxide 

Downstream Products

• 1356187-61-5 8-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}-1,4-dioxaspiro[4.5]decan-8-ol 
• 1356187-49-9 1-{chloro(phenyl)[(4-tolyl)sulfinyl]methyl}cyclobutanol 
• 451-40-1 phenyl benzyl ketone 
• 947-91-1 Diphenylacetaldehyde 
• 14996-78-2 2-phenylcycloheptanone 
• 1356187-26-2 C₁₆H₁₅⁽²⁾HO 
• 1356187-32-0 1,4-diphenylhept-6-en-3-one 
• 56741-24-3 1,2,5-triphenylpentan-3-one 
• 1356187-80-8 9-phenyl-1,4-dioxaspiro[4.6]undecan-8-one 
• 1356187-95-5 9-deuterio-9-phenyl-1,4-dioxaspiro[4.6]undecan-8-one 
• 1356188-01-6 9-allyl-9-phenyl-1,4-dioxaspiro[4.6]undecan-8-one 
• 1356188-05-0 9-benzyl-9-phenyl-1,4-dioxaspiro[4.6]undecan-8-one 
• 1356188-07-2 9-benzoyl-9-phenyl-1,4-dioxaspiro[4.6]undecan-8-one 
• 1444-65-1 (RS)-2-phenylcyclohexanone 

Relevant articles and documents

Aryl(chloro)methyl 4-tolyl sulfoxides: Synthesis and application to the synthesis of α-aryl ketones

Aryl(chloro)methyl 4-tolyl sulfoxides were synthesized from arylmethyl 4-tolyl sulfoxides in moderate-to-good yields by sequential treatment with lithium diisopropylamide and tosyl chloride at low temperatures. Treatment of the lithium α-sulfinyl carbanion of the aryl(chloro)methyl 4-tolyl sulfoxides with aldehydes or ketones resulted in the formation of adducts in good-to-high yields. Treatment of these adducts with tert-butylmagnesium chloride gave the corresponding magnesium alkoxides. On treatment with isopropylmagnesium chloride, the alkoxides gave the corresponding magnesium β-oxido carbenoids, which rearranged to give α-aryl ketones in good-to-high yields. The magnesium enolate intermediates generated by rearrangement of the -oxido carbenoids could also be trapped with electrophiles to give α-aryl α-substituted ketones. These procedures offer a good method for the synthesis of a variety of α-aryl ketones from aldehydes and ketones. Georg Thieme Verlag Stuttgart. New York.