N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide
• CAS No.: 104704-82-7
• Molecular Formula: C₂₃H₂₇N₃O₂S
• Molecular Weight: 409.552
• Mol file: 104704-82-7.mol

Synonyms:N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide

Chemical Property of N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide

There total 3 articles about N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N,N-Bis-(4-cyano-benzyl)-4-methyl-benzenesulfonamide (104704-81-6) → N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide (104704-82-7)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)98911-1

Reference yield:

toluene-4-sulfonamide (70-55-3) → N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide (104704-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

2: 1.) B₂H₆ 2.) 6N HCl / 1.) THF, room temperature, 16 h 2.) room temperature, 18 h

With hydrogenchloride; potassium carbonate; diborane; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)82024-9

Reference yield:

4-cyanobenzyl bromide (17201-43-3) → N,N-Bis-(4-aminomethyl-benzyl)-4-methyl-benzenesulfonamide (104704-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 3 h / 60 °C

2: 1.) B₂H₆ 2.) 6N HCl / 1.) THF, room temperature, 16 h 2.) room temperature, 18 h

With hydrogenchloride; potassium carbonate; diborane; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)82024-9

upstream raw materials:

N,N-Bis-(4-cyano-benzyl)-4-methyl-benzenesulfonamide

toluene-4-sulfonamide

4-cyanobenzyl bromide

Downstream raw materials:

C₄₆H₄₄N₄O₆S₂

C₃₇H₃₉N₃O₆S₃

N,N',N''-tritosyl-2,11,20-triaza<3.3.3>paracyclophane