(S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1146159-96-7
Molecular Formula:C₁₃H₁₉ClN₄O₂
Molecular Weight:298.772
Hs Code.:
Mol file:1146159-96-7.mol

Synonyms:(S)-tert-butyl 3-(2-chloropyrimidin-4-ylamino)pyrrolidine-1-carboxylate

Suppliers and Price of (S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (S)-3-(2-Chloro-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3934-20-1
2,6-Dichloropyrimidine

: 147081-44-5
(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

: 1146159-96-7,945895-38-5,1289585-47-2
(S)-tert-butyl 3-(2-chloropyrimidin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 24h;

Reference yield: 87.0%

: 1146159-96-7,945895-38-5,1289585-47-2
(S)-tert-butyl 3-(2-chloropyrimidin-4-ylamino)pyrrolidine-1-carboxylate

: 371-40-4
4-fluoroaniline

: C₁₄H₁₆FN₅

Guidance literature:: (S)-tert-butyl 3-(2-chloropyrimidin-4-ylamino)pyrrolidine-1-carboxylate; 4-fluoroaniline; With trifluoroacetic acid; In 1,4-dioxane; at 100 ℃; for 5h;

With trifluoroacetic acid; for 1h;
DOI:10.1039/c8ob02599a