rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

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Chemical Name:rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone
CAS No.:1582759-07-6
Molecular Formula:C₂₀H₁₉F₃N₆O
Molecular Weight:416.406
Hs Code.:

Synonyms:rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

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Chemical Property of rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

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Technology Process of rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

There total 5 articles about rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582753-88-5
N-(3-ethynyl-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-amine

: 3-azido-cyclohexan-1-one

: 1582759-07-6
rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 65 ℃; for 2h;

Reference yield:

: 74586-53-1
3-bromo-5-methylaniline

: 1582759-07-6
rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 1,4-dioxane / Reflux

2: tris-(o-tolyl)phosphine; diisopropylamine; palladium diacetate / acetonitrile / 3 h / 75 °C / Inert atmosphere

3: potassium carbonate; methanol / 3 h

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 2 h / 65 °C

With methanol; copper(ll) sulfate pentahydrate; methanesulfonic acid; palladium diacetate; potassium carbonate; sodium L-ascorbate; diisopropylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1582759-07-6
rac-3-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 1,4-dioxane / Reflux

2: tris-(o-tolyl)phosphine; diisopropylamine; palladium diacetate / acetonitrile / 3 h / 75 °C / Inert atmosphere

3: potassium carbonate; methanol / 3 h

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 2 h / 65 °C

With methanol; copper(ll) sulfate pentahydrate; methanesulfonic acid; palladium diacetate; potassium carbonate; sodium L-ascorbate; diisopropylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;