74586-53-1

Usage

Uses

3-Bromo-5-methylaniline is used as pharmaceutical intermediates and chemical intermediate.

InChI:InChI=1/C7H8BrN/c1-5-2-6(8)4-7(9)3-5/h2-4H,9H2,1H3

Upstream product

• 96558-69-9 2,3-Dibromo-5-methylaniline 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 52488-28-5 1-bromo-3-methyl-5-nitrobenzene 

Downstream Products

• 102236-11-3 3-bromo-N,N,5-trimethylaniline 
• 5326-49-8 N-(3-bromo-5-methylphenyl)acetamide 
• 61563-25-5 2,3-dibromotoluene 
• 1263376-30-2 3,4-dibromo-5-methyl-aniline 
• 603-78-1 2,3-dibromobenzoic acid 
• 39664-46-5 2,3,4,6-tetrabromotoluene 
• 594862-62-1 N-(3-bromo-5-methylphenyl)urea 

Relevant academic research and scientific papers

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

PHENYLETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I),to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Copper(I)-Induced Halogen-Hydrogen Exchange of 2-Halogenoanilines

The copper(I)-induced halogen-hydrogen exchange in the 2-position of 2,3-dibromoaniline, 2,3-dibromo-5-methylaniline, 2,3-dibromo-5-chloroaniline and 3-bromo-2-iodoaniline has been studied in acetic acid, ethanol and chlorobenzene media with a hydrochloric acid content of 0.56 mol dm-3.The CuX32- complexes used in the reduction reaction are (CH3Ph3P+)2CuBr32-, (CH3PH3P+)2CuI32-, (NH4+)2CuBr32- and (NH4+)2CuCl32-. (C4H9)4N+ CuCl2- and NH4+ CuBr2- have also been tested in the same media.The reduction rate increases with the size of the Cu(I)-complex.

Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders

4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C 1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II STR1 wherein R 2 represents carboxy or a group convertible thereto in vivo, R 6 is hydrogen and R 5 and R 7 represent C 1-6 alkyl or halogen, provided that R 5 and R 7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.

The Kinetics of the Reactions of Picryl Chloride with Some Substituted Anilines. Part 5.

Arrhenius parameters have been measured for the reactions of picryl chloride with the following substituted anilines in acetonitrile: 3-amino- and 3-methyl-aniline, 3-amino-5-nitroaniline, 3-fluoro-5-methylsulphonylaniline, 3-X-5-methylanilines (X=NO2, OMe, CH3, F, Cl, Br, or I) and 3,5-X2-anilines (X = F, Cl, Br, or I).A total of 33 3,5-disubstituted anilines have now been examined for the additivity of substituent effects on the free energy of activation, and it has been shown that with the exception of 3-amino-5-nitroaniline this hypothesis reproduces experimental rate constants within a factor of 2.A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.