74586-53-1

Basic information

• Product Name: 3-bromo-5-methylaniline
• Synonyms: 3-bromo-5-methylaniline;3-Bromo-5-methylbenzenamine;3-Amino-5-bromotoluene, 5-Bromo-m-toluidine;3-AMino-5-broMotoluene;BenzenaMine,3-broMo-5-Methyl-
• CAS NO: 74586-53-1
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.04912
• EINECS: 277-932-1
• Mol File: 74586-53-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 37 °C
• Boiling Point: 257.5 °C at 760 mmHg
• Flash Point: 111.7 °C
• Appearance: Brown/Powder
• Density: 1.498 g/cm³
• Vapor Pressure: 0.0145mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.65±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-bromo-5-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-methylaniline(74586-53-1)
• EPA Substance Registry System: 3-bromo-5-methylaniline(74586-53-1)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 74586-53-1(Hazardous Substances Data)

Usage

Uses

3-Bromo-5-methylaniline is used as pharmaceutical intermediates and chemical intermediate.

InChI:InChI=1/C7H8BrN/c1-5-2-6(8)4-7(9)3-5/h2-4H,9H2,1H3

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 96558-69-9 2,3-Dibromo-5-methylaniline 
• 52488-28-5 1-bromo-3-methyl-5-nitrobenzene 

Downstream Products

• 1570257-08-7 3'-methyl-5'-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-3-carbonitrile 
• 1570259-25-4 N-[5-methyl-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-4-(trifluoromethyl)pyrimidin-2-amine 
• 1378998-35-6 N-(3-bromo-5-methylphenyl)-4-chloropyrimidin-2-amine 
• 1378998-34-5 2-[(3-bromo-5-methylphenyl)amino]pyrimidin-4(3H)-one 
• 1312535-22-0 N-(3-bromo-5-methylphenyl)-4-methylpyrimidin-2-amine 
• 1269233-13-7 N-(3-bromo-5-methylphenyl)propane-2-sulfonamide 
• 594862-62-1 N-(3-bromo-5-methylphenyl)urea 
• 504-15-4 orcinol 
• 39664-46-5 2,3,4,6-tetrabromotoluene 
• 603-78-1 2,3-dibromobenzoic acid 
• 1263376-30-2 3,4-dibromo-5-methyl-aniline 
• 61563-25-5 2,3-dibromotoluene 
• 202865-83-6 1-bromo-3-fluoro-5-methylbenzene 
• 5326-49-8 N-(3-bromo-5-methylphenyl)acetamide 

Relevant articles and documents

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I),to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Copper(I)-Induced Halogen-Hydrogen Exchange of 2-Halogenoanilines

The copper(I)-induced halogen-hydrogen exchange in the 2-position of 2,3-dibromoaniline, 2,3-dibromo-5-methylaniline, 2,3-dibromo-5-chloroaniline and 3-bromo-2-iodoaniline has been studied in acetic acid, ethanol and chlorobenzene media with a hydrochloric acid content of 0.56 mol dm-3.The CuX32- complexes used in the reduction reaction are (CH3Ph3P+)2CuBr32-, (CH3PH3P+)2CuI32-, (NH4+)2CuBr32- and (NH4+)2CuCl32-. (C4H9)4N+ CuCl2- and NH4+ CuBr2- have also been tested in the same media.The reduction rate increases with the size of the Cu(I)-complex.