4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

Base Information

Chemical Name:4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde
CAS No.:1446236-22-1
Molecular Formula:C₂₂H₁₆F₂N₂O₅S
Molecular Weight:458.442
Hs Code.:

Synonyms:4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

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Chemical Property of 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

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Technology Process of 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

There total 11 articles about 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1446235-08-0
4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-2-(hydroxymethyl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

: 1446236-22-1
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3.5h;

Reference yield:

: 367-27-1
2,4-difluorophenol

: 1446236-22-1
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 120 °C

2.1: palladium 10% on activated carbon; hydrogen / 24 h / 40 °C / 1551.49 Torr

3.1: hydrogenchloride / 1,4-dioxane; water / 0.17 h / 0 °C

3.2: 1 h / 0 °C

3.3: 2 h / 10 °C

4.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.5 h / Inert atmosphere

4.2: 16 h / 60 °C

5.1: trifluoroacetic acid; sulfuric acid; methoxybenzene / 4 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7.1: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

With hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium carbonate; Dess-Martin periodane; methoxybenzene; trifluoroacetic acid; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1099246-47-5
1-(2,4-difluorophenoxy)-4-(methylsulfonyl)-2-nitrobenzene

: 1446236-22-1
4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / 24 h / 40 °C / 1551.49 Torr

2.1: hydrogenchloride / 1,4-dioxane; water / 0.17 h / 0 °C

2.2: 1 h / 0 °C

2.3: 2 h / 10 °C

3.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.5 h / Inert atmosphere

3.2: 16 h / 60 °C

4.1: trifluoroacetic acid; sulfuric acid; methoxybenzene / 4 h / 90 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

6.1: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

With hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; sulfuric acid; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; methoxybenzene; trifluoroacetic acid; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;