Technology Process of 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-2-(hydroxymethyl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
There total 10 articles about 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-2-(hydroxymethyl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 120 °C
2.1: palladium 10% on activated carbon; hydrogen / 24 h / 40 °C / 1551.49 Torr
3.1: hydrogenchloride / 1,4-dioxane; water / 0.17 h / 0 °C
3.2: 1 h / 0 °C
3.3: 2 h / 10 °C
4.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.5 h / Inert atmosphere
4.2: 16 h / 60 °C
5.1: trifluoroacetic acid; sulfuric acid; methoxybenzene / 4 h / 90 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
With
hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium carbonate; methoxybenzene; trifluoroacetic acid; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane;
In
tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / 1,4-dioxane; water / 0.17 h / 0 °C
1.2: 1 h / 0 °C
1.3: 2 h / 10 °C
2.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 0.5 h / Inert atmosphere
2.2: 16 h / 60 °C
3.1: trifluoroacetic acid; sulfuric acid; methoxybenzene / 4 h / 90 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
With
hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; sulfuric acid; methoxybenzene; trifluoroacetic acid; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane;
In
tetrahydrofuran; 1,4-dioxane; water;
![ethyl 4-(2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1 H-pyrrolo[2,3-c]pyridine-2-carboxylate](/Databaselist/images/loading.webp)
