ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

Base Information

Chemical Name:ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate
CAS No.:1221274-99-2
Molecular Formula:C₁₈H₂₂IN₃O₃
Molecular Weight:455.295
Hs Code.:

Synonyms:ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

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Chemical Property of ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

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Technology Process of ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

There total 3 articles about ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 229171-07-7
1-(benzyloxy)-4-iodo-1H-pyrazole

: 1221274-99-2
ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

1.2: 0 - 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 65 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

3.2: -78 - 20 °C

With triethylsilane; isopropylmagnesium chloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: |Grignard Reaction / 1.2: |Grignard Reaction;
DOI:10.1021/acschemneuro.9b00478

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1221274-99-2
ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

1.2: 0 - 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 65 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

3.2: -78 - 20 °C

With triethylsilane; isopropylmagnesium chloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: |Grignard Reaction / 1.2: |Grignard Reaction;
DOI:10.1021/acschemneuro.9b00478

Reference yield:

: C₁₈H₂₃N₃O₄

: 1221274-99-2
ethyl 4-(1-(benzyloxy)-5-iodo-1H-pyrazol-4-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 65 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

2.2: -78 - 20 °C

With triethylsilane; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acschemneuro.9b00478