(1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

Base Information

Chemical Name:(1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine
CAS No.:1205536-97-5
Molecular Formula:C₂₆H₃₉NOSi
Molecular Weight:409.687
Hs Code.:

Synonyms:(1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

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Technology Process of (1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

There total 7 articles about (1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1205536-95-3
benzyl (1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutylcarbamate

: 1205536-97-5
(1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃;

Reference yield:

: 1205536-82-8
(S,E)-8-(tert-butyldiphenylsilyloxy)-2-methyloct-5-en-4-amine hydrochloride

: 1205536-97-5
(1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: diethylzinc / dichloromethane; 1,2-dimethoxyethane / 0.23 h / -20 - 20 °C / Inert atmosphere

2.2: 10 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 8 h / 20 °C / 760.05 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; diethylzinc; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1205536-97-5
(1S)-1-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)cyclopropyl)-3-methylbutan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 22 h / 20 °C

2.1: Schwartz's reagent / dichloromethane / 0.17 h / 20 °C

2.2: 0.08 h / 0 °C

2.3: 4 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: diethylzinc / dichloromethane; 1,2-dimethoxyethane / 0.23 h / -20 - 20 °C / Inert atmosphere

4.2: 10 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 8 h / 20 °C / 760.05 Torr / Inert atmosphere

With 1H-imidazole; Schwartz's reagent; palladium 10% on activated carbon; hydrogen; diethylzinc; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;