DIETHYL 3-BROMOPROPYLMALONATE

Base Information

• Chemical Name: DIETHYL 3-BROMOPROPYLMALONATE
• CAS No.: 10149-21-0
• Molecular Formula: C10H17 Br O4
• Molecular Weight: 281.147
• Hs Code.: 2917190090
• Mol file: 10149-21-0.mol

Synonyms:Malonicacid, (3-bromopropyl)-, diethyl ester (6CI,7CI,8CI); Propanedioic acid,(3-bromopropyl)-, diethyl ester (9CI); Diethyl 2-(3-bromopropyl)malonate;Diethyl 3-bromopropylmalonate

Chemical Property of DIETHYL 3-BROMOPROPYLMALONATE

Chemical Property:

• Boiling Point: 150-155 °C(Press: 10 Torr)
• PKA: 12.62±0.59(Predicted)
• PSA: 52.60000
• Density: 1.286 g/cm3
• LogP: 1.90390
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diethyl3-Bromopropylmalonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Byproduct formed during the production of Carboplatin

Technology Process of DIETHYL 3-BROMOPROPYLMALONATE

There total 2 articles about DIETHYL 3-BROMOPROPYLMALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

1,3-dibromo-propane (109-64-8) + diethyl malonate (105-53-3) → diethyl 2-(3-bromopropane)malonate (10149-21-0) + diethyl cyclobutane-1,1-dicarboxylate (3779-29-1)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide;

Reference yield:

sodium diethylmalonate (996-82-7) + 1,3-dibromo-propane (109-64-8) → diethyl 2-(3-bromopropane)malonate (10149-21-0) + diethyl cyclobutane-1,1-dicarboxylate (3779-29-1)

Guidance literature:

Reference yield: 27.0%

diethyl 2-(3-bromopropane)malonate (10149-21-0) + 5-(4-hydroxyphenyl)-10,15,20-tri(p-tolyl)porphyrin (57412-08-5) → 5-[4-[4,4-bis(ethoxycarbonyl)butyloxy]phenyl]-10,15,20-tritolylporphyrin

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1007/s00706-011-0586-3

upstream raw materials:

1,3-dibromo-propane

diethyl malonate

sodium diethylmalonate

Downstream raw materials:

(4-cyano-4,4-diphenyl-butyl)-malonic acid

diethyl cyclobutane-1,1-dicarboxylate

5-bromopentanoic acid

3-carboethoxy-2-pyridone

Refernces

• 1、 Zefirov, N. S.,Kuznetsova, T. S.,Kozhushkov, S. I.,Surmina, L. S.,Rashchupkina, Z. A.. "CYCLOALKYLATION BY THE α,ω-DIBROMIDES OF COMPOUNDS CONTAINING AN ACTIVATED METHYLENE GROUP AS A METHOD FOR THE SYNTHESIS OF 1,1-DISUBSTITUTED CYCLOALKENES". . p. 474 - 480. Retrieved 2007/10/02.