6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester
CAS No.:80021-77-8
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

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Chemical Property of 6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

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Technology Process of 6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

There total 8 articles about 6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20807-64-1
4-methyl-2-(4-nitrophenyl)pyridine

: 80021-77-8
6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: H₂, AcONa / 10percent Pd/C / dimethylformamide

5: SOCl₂ / 4 h / Heating

6: 75 percent / aq. NaHCO₃ / ethyl acetate / 0.75 h

7: K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; thionyl chloride; hydrogen; dihydrogen peroxide; sodium acetate; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfate; palladium on activated charcoal; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-65-4
4-methyl-2-(4-nitrophenyl)pyridine N-oxide

: 80021-77-8
6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

2: 5 M aq. HCl / 11 h / Heating

3: H₂, AcONa / 10percent Pd/C / dimethylformamide

4: SOCl₂ / 4 h / Heating

5: 75 percent / aq. NaHCO₃ / ethyl acetate / 0.75 h

6: K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; thionyl chloride; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-68-7
2-cyano-4-methyl-6-(4-nitrophenyl)pyridine

: 80021-77-8
6-[4-(Benzyloxycarbonyl-methyl-amino)-phenyl]-4-methyl-pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 5 M aq. HCl / 11 h / Heating

2: H₂, AcONa / 10percent Pd/C / dimethylformamide

3: SOCl₂ / 4 h / Heating

4: 75 percent / aq. NaHCO₃ / ethyl acetate / 0.75 h

5: K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; thionyl chloride; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026