Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)
• CAS No.: 10132-25-9
• Molecular Formula: C6H8 N2 S
• Molecular Weight: 140.209
• Mol file: 10132-25-9.mol

Synonyms:2-(Ethylthio)pyrimidine;2-Ethylmercaptopyrimidine

Chemical Property of Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)

Chemical Property:

• PSA: 51.08000
• LogP: 1.58860

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI)

There total 10 articles about Pyrimidine, 2-(ethylthio)- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromopyrimidine (4595-60-2) + ethanethiol (75-08-1) → 2-(ethylsulfanyl)pyrimidine (10132-25-9)

Guidance literature:

ethanethiol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

2-bromopyrimidine; With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In tetrahydrofuran; toluene; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201806036

Reference yield: 81.0%

4-chloro-2-ethylthio-5-iodopyrimidine (104705-27-3) → 2-(ethylsulfanyl)pyrimidine (10132-25-9)

Guidance literature:

With sodium hydroxide; hydrogen; palladium on activated charcoal; at 20 ℃; for 12h; under 1275.1 Torr;

Reference yield: 80.0%

ethylmagnesium bromide (925-90-6) + 2-thiocyanatopyrimidine (89283-87-4) → 2-(ethylsulfanyl)pyrimidine (10132-25-9)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1h;

upstream raw materials:

4-chloro-2-ethylsulfanyl-pyrimidine

4-chloro-2-ethylthio-5-iodopyrimidine

ethyl iodide

2-sulfanylpyrimidine

Downstream raw materials:

2-pyrimidinone hydrochloride

Trimethylenediamine