METHYL 3-HYDROXYISONICOTINATE

Base Information

• Chemical Name: METHYL 3-HYDROXYISONICOTINATE
• CAS No.: 10128-72-0
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 29333990
• Mol file: 10128-72-0.mol

Synonyms:Isonicotinicacid, 3-hydroxy-, methyl ester (7CI,8CI);3-Hydroxypyridine-4-carboxylic acid methyl ester;

Chemical Property of METHYL 3-HYDROXYISONICOTINATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 74-76 °C
• Refractive Index: 1.552
• Boiling Point: 313.557 °C at 760 mmHg
• PKA: 6.92±0.10(Predicted)
• Flash Point: 143.434 °C
• PSA: 59.42000
• Density: 1.287 g/cm³
• LogP: 0.57380
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-hydroxyisonicotinate ^*data from reagent suppliers

Safty Information:

• Statements: 20/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-HYDROXYISONICOTINATE

There total 3 articles about METHYL 3-HYDROXYISONICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + 3-hydroxyisonicotinic acid (10128-71-9) → methyl 3-hydroxypyridine-4-carboxylate (10128-72-0)

Guidance literature:

With sulfuric acid; for 15h; Heating;

DOI:10.1016/j.molstruc.2007.06.012

Reference yield:

methyl 3-aminoisonicotinate (55279-30-6) → methyl 3-hydroxypyridine-4-carboxylate (10128-72-0)

Guidance literature:

With sulfuric acid; sodium nitrite; anschliessendes Erwaermen des Reaktionsgemisches;

DOI:10.1021/jo01138a006

Reference yield:

→ methyl 3-hydroxypyridine-4-carboxylate (10128-72-0)

Guidance literature:

entspr. Saeure, Me. (Veresterung);

upstream raw materials:

methanol

3-hydroxyisonicotinic acid

methyl 3-aminoisonicotinate

Downstream raw materials:

3-Hydroxy-4-hydroxymethyl-pyridin

isonicotinoylhydrazide

3,N-dihydroxy-isonicotinamide

4-(hydroxymethyl)-3-methoxypyridine

Refernces

• 1、 -. "GRK2 INHIBITORS AND USES THEREOF". Page/Page column 66; 70-71. . Retrieved 2021/12/08.
• 2、 -. "SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION". Paragraph 0159. . Retrieved 2013/07/19.