1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

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Chemical Name:1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione
CAS No.:1555932-55-2
Molecular Formula:C₃₈H₄₇N₅O₄
Molecular Weight:637.822
Hs Code.:

Synonyms:1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

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Chemical Property of 1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

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Technology Process of 1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

There total 3 articles about 1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 220615-80-5
3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

: 1-((1R,1'R,3R,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-chloroquinoxalin-2(1H)-one

: 1555932-55-2
1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

Guidance literature:: 3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 0 ℃; for 0.5h;

1-((1R,1'R,3R,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-chloroquinoxalin-2(1H)-one; In N,N-dimethyl acetamide; mineral oil; at 80 ℃; for 1h;

Reference yield:

: 1384190-02-6
1-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)quinoxaline-2,3(1H,4H)-dione

: 1555932-55-2
1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux

2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 0 °C

2.2: 1 h / 80 °C

With thionyl chloride; sodium hydride; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl acetamide; mineral oil;

Reference yield:

: 77-71-4
5,5-dimethyl-imidazolidine-2,4-dione

: 824-94-2
p-methoxybenzyl chloride

: 1555932-55-2
1-(4-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxalin-2-yl)-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 25 - 90 °C

1.2: 25 - 60 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 0 °C

2.2: 1 h / 80 °C

With sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl acetamide; mineral oil;