2-deuteriobenzaldehyde

Base Information

• Chemical Name: 2-deuteriobenzaldehyde
• CAS No.: 66154-03-8
• Molecular Formula: C₇H₆O
• Molecular Weight: 107.116
• Mol file: 66154-03-8.mol

Synonyms:2-deuteriobenzaldehyde

Chemical Property of 2-deuteriobenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-deuteriobenzaldehyde

There total 19 articles about 2-deuteriobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromobenzaldehyde diethyl acetal (35822-58-3) → 2-deuteriobenzaldehyde (66154-03-8)

Guidance literature:

2-bromobenzaldehyde diethyl acetal; With n-butyllithium; deuteromethanol;

With hydrogenchloride;

DOI:10.1002/anie.201502553

Reference yield: 92.0%

2-(2-bromophenyl)-1,3-dioxolan (34824-58-3) → 2-deuteriobenzaldehyde (66154-03-8)

Guidance literature:

2-(2-bromophenyl)-1,3-dioxolan; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h; Inert atmosphere;

In diethyl ether; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201901864

Reference yield: 61.0%

2-deuterobenzylidenedichloride (50535-19-8) → 2-deuteriobenzaldehyde (66154-03-8)

Guidance literature:

With sulfuric acid; at 0 ℃; for 2h;

DOI:10.1016/S0022-328X(99)00082-0

upstream raw materials:

2-deuteriotoluene

1-bromomethyl-2-deuterio-benzene

2-deuterobenzylidenedichloride

l'alcool benzylique o-deuterie

Downstream raw materials:

C₁₀H₈⁽²⁾HN₃O₂

2-deuteriobenzoic acid

d₂-benzoyl chloride

4-phenylimidazo<1,2-c>quinazoline

Refernces

• 1、 Jin, Long,Zhang, Xing-Long,Guo, Rui-Li,Wang, Meng-Yue,Gao, Ya-Ru,Wang, Yong-Qiang. "Palladium-Catalyzed Dehydrogenative Fluoroalkoxylation of Benzaldehydes". supporting information. p. 1921 - 1927. Retrieved 2021/03/08.
• 2、 Hong, Feng-Lin,Wang, Ze-Shu,Wei, Dong-Dong,Zhai, Tong-Yi,Deng, Guo-Cheng,Lu, Xin,Liu, Rai-Shung,Ye, Long-Wu. "Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Diyne Cyclization: Enantioselective and Divergent Synthesis of Chiral Polycyclic Pyrroles". supporting information. p. 16961 - 16970. Retrieved 2019/10/16.