ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

Base Information

Chemical Name:ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate
CAS No.:1450742-96-7
Molecular Formula:C₂₁H₂₅FN₂O₄S
Molecular Weight:420.505
Hs Code.:

Synonyms:ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

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Chemical Property of ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

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Technology Process of ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

There total 1 articles about ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1450742-88-7
ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate

: 109-55-7
1-amino-3-(dimethylamino)propane

: 1450742-96-7
ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.05.067

Reference yield: 100.0%

: 1450742-96-7
ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

: 1450742-97-8
ethyl 5-(3-(dimethylamino)propyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 20 - 80 ℃; for 2h;
DOI:10.1016/j.bmc.2013.05.067

Reference yield:

: 1450742-96-7
ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

: 1450742-98-9
5-(3-(dimethylamino)propyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 2 h / 20 - 80 °C

2: sodium hydroxide / tetrahydrofuran; ethanol / 6 h / 80 °C

With toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmc.2013.05.067