2-(2-Methoxy-phenyl)-benzothiazole

Base Information

• Chemical Name: 2-(2-Methoxy-phenyl)-benzothiazole
• CAS No.: 10002-44-5
• Molecular Formula: C14H11 N O S
• Molecular Weight: 241.313
• Hs Code.: 2934999090
• Mol file: 10002-44-5.mol

Synonyms:Benzothiazole,2-(m-methoxyphenyl)- (7CI); 2-(3-Methoxyphenyl)benzo[d]thiazole;2-(3-Methoxyphenyl)benzothiazole; 2-(3'-Methoxyphenyl)benzothiazole

Chemical Property of 2-(2-Methoxy-phenyl)-benzothiazole

Chemical Property:

• PSA: 50.36000
• LogP: 3.97190

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3-METHOXYPHENYL)-1,3-BENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Methoxy-phenyl)-benzothiazole

There total 44 articles about 2-(2-Methoxy-phenyl)-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-methoxy-benzaldehyde (591-31-1) + 2-amino-benzenethiol (137-07-5) → 2-(3'-methoxyphenyl)benzothiazole (10002-44-5)

Guidance literature:

With Cu(II) containing nanosilica triazine dendrimer; In neat (no solvent); at 20 ℃; for 0.666667h; Catalytic behavior;

DOI:10.1016/j.molcata.2013.08.009

Reference yield: 96.0%

2-iodophenylamine (615-43-0) + m-methoxybenzyl chloride (824-98-6) → 2-(3'-methoxyphenyl)benzothiazole (10002-44-5)

Guidance literature:

With copper(II) acetate monohydrate; sodium carbonate; sulfur; In dimethyl sulfoxide; at 130 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.05.004

Reference yield: 96.0%

2-amino-benzenethiol (137-07-5) + m-methoxybenzyl chloride (824-98-6) → 2-(3'-methoxyphenyl)benzothiazole (10002-44-5)

Guidance literature:

With pyridine; sulfur; at 130 ℃; for 20h; Inert atmosphere;

DOI:10.1002/asia.201600355

upstream raw materials:

3-methoxybenzoic acid anhydride

2-amino-benzenethiol

m-anisoyl chloride

3-methoxybenzonitrile

Downstream raw materials:

3-benzothiazol-2-yl-phenol

O-[3-(1,3-benzothiazol-2-yl)phenyl]diphenylthiophosphinate

Refernces

• 1、 Ding, Mei-Fang,Chen, Chia-Pei,Lin, Shaw-Tao. "Alumina as a support and catalyst for the synthesis of benzothiazoles in solvent-free condition". . p. 645 - 649. Retrieved 2013.
• 2、 Ranu, Brindaban C.,Jana, Ranjan,Dey, Suvendu S.. "An efficient and green synthesis of 2-arylbenzothiazoles in an ionic liquid, [pmIm]Br under microwave irradiation". . p. 274 - 275. Retrieved 2004.
• 3、 Wang, Xin,Miao, Dazhuang,Li, Xiaotong,Hu, Renhe,Yang, Zhao,Gu, Ren,Han, Shiqing. "Elemental sulfur mediated cyclization via redox strategy: Synthesis of benzothiazoles from o-chloronitrobenzenes and benzyl chlorides". . p. 5194 - 5199. Retrieved 2017.
• 4、 Chen, Xiuling,Chen, Tieqiao,Zhou, Yongbo,Han, Daoqing,Han, Li-Biao,Yin, Shuang-Feng. "Metal-free aerobic oxidative C-N bond cleavage of tertiary amines for the synthesis of N-heterocycles with high atom efficiency". . p. 3802 - 3807. Retrieved 2014.
• 5、 Khemnar, Ashok B.,Bhanage, Bhalchandra M.. "Iron catalyzed efficient synthesis of 2-arylbenzothiazoles from benzothiazole and olefins using environmentally benign molecular oxygen as oxidant". . p. 8939 - 8942. Retrieved 2014.
• 6、 Nale, Deepak B.,Bhanage, Bhalchandra M.. "N-Substituted Formamides as C1-Sources for the Synthesis of Benzimidazole and Benzothiazole Derivatives by Using Zinc Catalysts". . p. 2835 - 2842. Retrieved 2015.
• 7、 Shi, Xinkang,Guo, Junmei,Liu, Jianping,Ye, Mingde,Xu, Qing. "Unexpectedly Simple Synthesis of Benzazoles by tBuONa-Catalyzed Direct Aerobic Oxidative Cyclocondensation of o-Thio/Hydroxy/Aminoanilines with Alcohols under Air". . p. 9988 - 9993. Retrieved 2015.
• 8、 Cheng, Yannan,Yang, Jun,Qu, Yue,Li, Pixu. "Aerobic visible-light photoredox radical C-H functionalization: Catalytic synthesis of 2-substituted benzothiazoles". . p. 98 - 101. Retrieved 2012.
• 9、 Boger. "-". . p. 2296. Retrieved 1978.
• 10、 Kamila, Sukanta,Zhang, Hongming,Biehl, Edward R.. "One-pot synthesis of 2-aryl-and 2-alkylbenzo-thiazoles under microwave irradiation". . p. 2119 - 2126. Retrieved 2005.