4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

Base Information

Chemical Name:4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole
CAS No.:294182-35-7
Molecular Formula:C₁₄H₁₁F₄NO₂
Molecular Weight:301.24
Hs Code.:

Synonyms:4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

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Chemical Property of 4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

Chemical Property:

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Technology Process of 4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

There total 3 articles about 4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.8%

: 1774-47-6
trimethylsulfoxonium iodide

: 294182-14-2
1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

: 294182-35-7
4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h;

1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone; In tetrahydrofuran; dimethyl sulfoxide; at 0 ℃; for 1h;
DOI:10.1248/cpb.48.982

Reference yield:

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 294182-35-7
4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cu / dimethylsulfoxide / 1 h / 20 °C

1.2: 39.2 percent / dimethylsulfoxide / 15 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 30.7 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

3.2: 59.8 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; copper; sodium hydride; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1248/cpb.48.982

Reference yield:

: 294182-03-9
ethyl 2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroacetate

: 294182-35-7
4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 30.7 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

2.2: 59.8 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1248/cpb.48.982