1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

Base Information

Chemical Name:1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone
CAS No.:294182-14-2
Molecular Formula:C₁₃H₉F₄NO₂
Molecular Weight:287.214
Hs Code.:

Synonyms:1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

Chemical Property:

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Technology Process of 1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

There total 2 articles about 1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.7%

: 348-57-2
2,4-difluorobromobenzene

: 294182-03-9
ethyl 2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroacetate

: 294182-14-2
1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

Guidance literature:: 2,4-difluorobromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

ethyl 2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroacetate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;
DOI:10.1248/cpb.48.982

Reference yield:

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 294182-14-2
1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Cu / dimethylsulfoxide / 1 h / 20 °C

1.2: 39.2 percent / dimethylsulfoxide / 15 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 30.7 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

With n-butyllithium; copper; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1248/cpb.48.982

Reference yield: 59.8%

: 1774-47-6
trimethylsulfoxonium iodide

: 294182-14-2
1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone

: 294182-35-7
4-[difluoro[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-3,5-dimethylisoxazole

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h;

1-(2,4-difluorophenyl)-2-(3,5-dimethyl-4-isoxazolyl)-2,2-difluoroethanone; In tetrahydrofuran; dimethyl sulfoxide; at 0 ℃; for 1h;
DOI:10.1248/cpb.48.982