P-NITROPHENYL VALERATE

Base Information

• Chemical Name: P-NITROPHENYL VALERATE
• CAS No.: 1956-07-6
• Molecular Formula: C11H13 N O4
• Molecular Weight: 223.229
• Mol file: 1956-07-6.mol

Synonyms:Valericacid, p-nitrophenyl ester (6CI,7CI,8CI); 4-Nitrophenyl pentanoate;4-Nitrophenyl valerate; p-Nitrophenol valerate; p-Nitrophenyl pentanoate;p-Nitrophenyl valerate

Chemical Property of P-NITROPHENYL VALERATE

Chemical Property:

• PSA: 72.12000
• LogP: 3.21360
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-NITROPHENYL VALERATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of P-NITROPHENYL VALERATE

There total 5 articles about P-NITROPHENYL VALERATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 1-iodo-butane (542-69-8) + carbon monoxide (201230-82-2) → p-nitrophenyl valerate (1956-07-6)

Guidance literature:

With rhodium(III) chloride; 1,3-bis-(diphenylphosphino)propane; sodium carbonate; sodium bromide; In 1,4-dioxane; at 120 ℃; for 24h; under 750.075 Torr; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acscatal.0c00933

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + valeric acid (109-52-4) → p-nitrophenyl valerate (1956-07-6)

Guidance literature:

Multistep reaction; (i) ClCO₂Et, Et₃N, DMF, (ii) /BRN= 1281877/;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + n-valeryl chloride (638-29-9) → p-nitrophenyl valerate (1956-07-6)

Guidance literature:

With iodine; magnesium; benzene;

upstream raw materials:

4-nitro-phenol

n-valeryl chloride

valeric acid

p-nitrophenyl hexanoate

Downstream raw materials:

p-nitrophenolate

pentanoate

4-nitro-phenol

valeric acid

Refernces

• 1、 Ai, Han-Jun,Li, Chong-Liang,Wang, Hai,Wu, Xiao-Feng. "Rhodium-Catalyzed Carbonylative Coupling of Alkyl Halides with Phenols under Low CO Pressure". . p. 5147 - 5152. Retrieved 2020/05/27.
• 2、 Barra, Monica,Rossi, Rita H. de. "Inhibition of the Hydrolysis of p-Nitrophenyl Esters by Association with an Erythromycin A Derivative". . p. 1758 - 1772. Retrieved 2007/10/02.