1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

Base Information

Chemical Name:1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt
CAS No.:219950-15-9
Molecular Formula:C₁₅H₁₁F₃N₄O
Molecular Weight:320.274
Hs Code.:

Synonyms:1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

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Chemical Property of 1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

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Technology Process of 1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

There total 4 articles about 1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 219949-99-2
1-(2-carboxyphenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

: 219950-15-9
1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

Guidance literature:: 1-(2-carboxyphenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt; With diphenylphosphoranyl azide; triethylamine; In tert-butyl alcohol; at 80 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1016/S0040-4020(02)00269-7

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 219950-15-9
1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: conc. HCl; NaNO₂ / H₂O; tetrahydrofuran / 0.25 h / -5 - 0 °C

1.2: H₂O; tetrahydrofuran; pyridine / 2 h / 0 - 10 °C

1.3: 17 percent / Ac₂O

2.1: 87 percent / NaOH / tetrahydrofuran; methanol; H₂O / 0.5 h

3.1: Et₃N; diphenylphosphoryl azide / 2-methyl-propan-2-ol / 18 h / 80 °C

3.2: 50 percent / 50 percent TFA / CH₂Cl₂ / 0.5 h

With hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; water; tert-butyl alcohol; 3.1: Curtius rearrangement;
DOI:10.1016/S0040-4020(02)00269-7

Reference yield:

: 64241-57-2
N-[2-(methyloxycarbonyl)phenyl]glycine

: 219950-15-9
1-(2-aminophenyl)-4-oxido-3-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolium inner salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: conc. HCl; NaNO₂ / H₂O; tetrahydrofuran / 0.25 h / -5 - 0 °C

1.2: H₂O; tetrahydrofuran; pyridine / 2 h / 0 - 10 °C

1.3: 17 percent / Ac₂O

2.1: 87 percent / NaOH / tetrahydrofuran; methanol; H₂O / 0.5 h

3.1: Et₃N; diphenylphosphoryl azide / 2-methyl-propan-2-ol / 18 h / 80 °C

3.2: 50 percent / 50 percent TFA / CH₂Cl₂ / 0.5 h

With hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; water; tert-butyl alcohol; 3.1: Curtius rearrangement;
DOI:10.1016/S0040-4020(02)00269-7