2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide

Base Information

• Chemical Name: 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide
• CAS No.: 1148008-69-8
• Molecular Formula: C₂₆H₁₈F₂N₄O₄S
• Molecular Weight: 520.516
• Mol file: 1148008-69-8.mol

Synonyms:2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide

Chemical Property of 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide

There total 3 articles about 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride (1086063-46-8) + C20H23BN2O3 → 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide (1148008-69-8)

Guidance literature:

With sodium carbonate; dichloro-1,1'-bis(diphosphino)ferrocene-palladium(II); In 1,4-dioxane; water; at 100 ℃; for 20h;

Reference yield:

6-iodo-3-phenylquinazolin-4(3H)-one + N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide (1083326-73-1) → 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide (1148008-69-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.6b00232

Reference yield:

aniline (62-53-3) → 2,4-difluoro-N-(2-methoxy-5-(4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide (1148008-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / toluene / 3.5 h / 110 °C

1.2: 110 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; In 1,4-dioxane; water; toluene; 2.1: |Suzuki Coupling;

DOI:10.1021/acsmedchemlett.6b00232

upstream raw materials:

N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride

N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

aniline