N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

Base Information

• Chemical Name: N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide
• CAS No.: 1086063-46-8
• Molecular Formula: C12H9BrF2N2O3S
• Molecular Weight: 379.182
• Hs Code.: 2935009090
• Mol file: 1086063-46-8.mol

Synonyms:N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

Chemical Property of N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

Chemical Property:

• Boiling Point: 435.2±55.0 °C(Predicted)
• PKA: 5.61±0.40(Predicted)
• PSA: 76.67000
• Density: 1.720±0.06 g/cm3(Predicted)
• LogP: 4.08550
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(5-Bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

There total 5 articles about N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

5-bromo-2-(methyloxy)-3-pyridinamine (884495-39-0) + 2,4-difluorobenzene-1-sulfonyl chloride (13918-92-8) → N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride (1086063-46-8)

Guidance literature:

5-bromo-2-(methyloxy)-3-pyridinamine; 2,4-difluorobenzene-1-sulfonyl chloride; With pyridine; at 0 - 20 ℃; for 19h;

With sodium hydroxide; In methanol; at 20 ℃; for 12h;

Reference yield: 45.0%

→ N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride (1086063-46-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride (1086063-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0 - 20 °C

2: tin(II) chloride dihdyrate / ethyl acetate / 4 h / Reflux

3: pyridine / 0 - 20 °C

With pyridine; tin(II) chloride dihdyrate; In methanol; ethyl acetate;

DOI:10.1016/j.bmcl.2011.12.136

upstream raw materials:

5-bromo-2-(methyloxy)-3-pyridinamine

2,4-difluorobenzene-1-sulfonyl chloride

5-bromo-2-chloro-3-nitropyridine

5-bromo-3-nitro-2-pyridone

Downstream raw materials:

2,4-difluoro-N-(2-methoxy-5-(4-(4-morpholinyl)pyrido[3,2-d]pyrimidin-6-yl)-3-pyridinyl)benzenesulfonamide

N-{6-[5-{[(2,4-difluorophenyl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide

GS⁽²⁶⁴⁾K₂₁₅₈

2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Refernces

• 1、 -. "PI3 KINASE INHIBITORS AND USES THEREOF". Paragraph 00190. . Retrieved 2021/10/15.
• 2、 -. "Imidazopyrazine derivative and synthesis method and application thereof". Paragraph 0096-0104. . Retrieved 2020/12/29.