benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

Base Information

Chemical Name:benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester
CAS No.:174757-67-6
Molecular Formula:C₃₂H₅₀N₂O₉
Molecular Weight:606.757
Hs Code.:

Synonyms:benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

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Chemical Property of benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

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Technology Process of benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

There total 4 articles about benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 13498-70-9
L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

: 32693-80-4
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleric acid

: 174757-67-6
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

Guidance literature:: With 4-methyl-morpholine; dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/0040-4020(95)00962-0

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 174757-67-6
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / DCC, dimethylaminopyridine / CH₂Cl₂ / 24 h / Ambient temperature

2: 99 percent / H₂ / 10percent Pd/C / methanol / 5 h / Ambient temperature

3: 81 percent / DCC, dimethylaminopyridine, N-methylmorpholine / CH₂Cl₂ / 12 h / Ambient temperature

With 4-methyl-morpholine; dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/0040-4020(95)00962-0

Reference yield:

: 13516-17-1
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

: 174757-67-6
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd/C / methanol / 5 h / Ambient temperature

2: 81 percent / DCC, dimethylaminopyridine, N-methylmorpholine / CH₂Cl₂ / 12 h / Ambient temperature

With 4-methyl-morpholine; dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/0040-4020(95)00962-0