(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

Base Information

Chemical Name:(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide
CAS No.:1392104-08-3
Molecular Formula:C₃₀H₄₉NO₄Si₂
Molecular Weight:543.894
Hs Code.:

Synonyms:(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

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Technology Process of (5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

There total 2 articles about (5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1392104-16-3
6-(tert-butyldiphenylsilyloxy)-(5S)-5-hydroxyl-N-methoxy-N-methylhexanamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1392104-08-3
(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 - 45 ℃; for 13h; Inert atmosphere;
DOI:10.1039/c2ob06802h

Reference yield:

: 175398-31-9
(S)-6-(tert-butyldiphenylsilyloxy)-5-hydroxyhexanoic acid δ-lactone

: 1392104-08-3
(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / dichloromethane; toluene / 0 °C

1.2: 0 - 20 °C

2.1: 1H-imidazole; dmap / dichloromethane / 13 h / 20 - 45 °C / Inert atmosphere

With 1H-imidazole; dmap; trimethylaluminum; In dichloromethane; toluene;
DOI:10.1039/c2ob06802h

Reference yield: 79.0%

: 1392104-08-3
(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide

: 1119-51-3
bromopentene

: 1392104-07-2
(10S)-10-(tert-butyldimethylsilyloxy)-11-(tert-butyldiphenylsilyloxy)undec-1-en-6-one

Guidance literature:: bromopentene; With iodine; magnesium; In diethyl ether; Inert atmosphere;

(5S)-5-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylhexanamide; In diethyl ether; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2ob06802h