2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

Base Information

Chemical Name:2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate
CAS No.:548740-15-4
Molecular Formula:C₁₈H₂₁F₆NO₆S
Molecular Weight:493.424
Hs Code.:

Synonyms:2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

There total 3 articles about 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 450409-87-7
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]-1-ethanol

: 548740-15-4
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1055/s-2003-36844

Reference yield:

: 130783-02-7
3,5-bis(trifluoromethyl)thiophenol

: 548740-15-4
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Et₃N / acetonitrile / 24 h / 20 °C

2: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1055/s-2003-36844

Reference yield:

: 450409-97-9
2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol

: 548740-15-4
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1055/s-2003-36844