(S)-N₁-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N₂-phenylthiourea

Base Information

• Chemical Name: (S)-N₁-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N₂-phenylthiourea
• CAS No.: 1394035-45-0
• Molecular Formula: C₂₃H₂₄N₂O₂S
• Molecular Weight: 392.522
• Mol file: 1394035-45-0.mol

Synonyms:(S)-N₁-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N₂-phenylthiourea

Chemical Property of (S)-N₁-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N₂-phenylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N₁-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N₂-phenylthiourea

There total 4 articles about (S)-N₁-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N₂-phenylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-amino-3-(4-benzyloxyphenyl)-1-propanol (85803-44-7) + phenyl isothiocyanate (103-72-0) → (S)-N1-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N2-phenylthiourea (1394035-45-0)

Guidance literature:

at 25 ℃; for 6h;

DOI:10.3184/174751912X13336487086374

Reference yield:

N-(tert-butoxycarbonyl)-L-tyrosine ethyl ester (72594-77-5,1241680-28-3) → (S)-N1-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N2-phenylthiourea (1394035-45-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: lithium aluminium tetrahydride / tetrahydrofuran

3: acetyl chloride / methanol; ethyl acetate

4: 6 h / 25 °C

With lithium aluminium tetrahydride; potassium carbonate; acetyl chloride; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.3184/174751912X13336487086374

Reference yield:

ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate (127132-32-5) → (S)-N1-((1-(4-benzyloxy)benzyl)-2-hydroxyethyl)-N2-phenylthiourea (1394035-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran

2: acetyl chloride / methanol; ethyl acetate

3: 6 h / 25 °C

With lithium aluminium tetrahydride; acetyl chloride; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.3184/174751912X13336487086374

upstream raw materials:

N-(tert-butoxycarbonyl)-L-tyrosine ethyl ester

ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate

benzyl bromide

(S)-2-amino-3-(4-benzyloxyphenyl)-1-propanol

Downstream raw materials:

(S)-4-(4-benzyloxybenzyl)-2-phenylimino-2-oxazolidine

(S)-4-(4-hydroxybenzyl)-2-phenylimino-2-oxazolidine