16ALPHA-METHYLPREGNENOLONE ACETATE

Base Information

• Chemical Name: 16ALPHA-METHYLPREGNENOLONE ACETATE
• CAS No.: 1863-41-8
• Molecular Formula: C24H36 O3
• Molecular Weight: 372.54
• Mol file: 1863-41-8.mol

Synonyms:Pregn-5-en-20-one,3b-hydroxy-16a-methyl-, acetate (6CI,8CI)

Chemical Property of 16ALPHA-METHYLPREGNENOLONE ACETATE

Chemical Property:

• PSA: 43.37000
• LogP: 5.33210

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16ALPHA-METHYLPREGNENOLONE ACETATE

There total 15 articles about 16ALPHA-METHYLPREGNENOLONE ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methylmagnesium bromide (75-16-1) + 16-dehydropregnenolone acetate (979-02-2) → 16α-methylpregn-5-en-3β-ol-20-one 3-acetate (1863-41-8)

Guidance literature:

methylmagnesium bromide; 16-dehydropregnenolone acetate; With copper(l) chloride; In tetrahydrofuran; at -10 - 0 ℃; for 0.333333h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -5 ℃; for 0.25h;

With water; In tetrahydrofuran; methanol; at 5 - 10 ℃; for 2h;

DOI:10.1134/S1070428011010052

Reference yield: 75.0%

trimethylaluminum (75-24-1) + 16-dehydropregnenolone acetate (979-02-2) → 16α-methylpregn-5-en-3β-ol-20-one 3-acetate (1863-41-8)

Guidance literature:

trimethylaluminum; 16-dehydropregnenolone acetate; With chloro-trimethyl-silane; copper(I) bromide; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.steroids.2010.05.008

Reference yield: 68.0%

methyllithium (917-54-4) + 16-dehydropregnenolone acetate (979-02-2) → 16α-methylpregn-5-en-3β-ol-20-one 3-acetate (1863-41-8)

Guidance literature:

methyllithium; With copper(l) iodide; In tetrahydrofuran; diethyl ether; at 0 ℃;

16-dehydropregnenolone acetate; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h;

upstream raw materials:

Dimethyldisulphide

3'-H-cyclopropa<16,17α>pregn-5-en-3β-ol-20-one 3-acetate

16α-thiocyanatomethylpregn-5-en-3β-ol-20-one 3-acetate

methylmagnesium bromide

Downstream raw materials:

16α-methyl-3β-hydroxy-5-pregnen-20-one