(S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

Base Information

Chemical Name:(S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one
CAS No.:251353-57-8
Molecular Formula:C₃₁H₃₈O₄Si
Molecular Weight:502.726
Hs Code.:

Synonyms:(S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

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Chemical Property of (S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

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Technology Process of (S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

There total 10 articles about (S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4S,5R,6R)-5-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-1,1-diethoxy-6-methyl-hept-1-en-4-ol

: 251353-57-8
(S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

Guidance literature:: (4S,5R,6R)-5-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-1,1-diethoxy-6-methyl-hept-1-en-4-ol; With potassium carbonate; In methanol;

With hydrogenchloride;
DOI:10.1016/S0040-4039(99)01322-2

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 251353-57-8
(S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethyl ether

2.1: NaH; n-BuI / tetrahydrofuran

3.1: OsO₄; NMO / H₂O; acetone

4.1: PPTS / CH₂Cl₂

5.1: CH₂Cl₂

5.2: K₂CO₃ / methanol

6.1: n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 °C

7.1: HgCl₂

8.1: K₂CO₃ / methanol

8.2: 3M HCl

With osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; 1-iodo-butane; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; mercury dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; 1.1: Addition / 2.1: Alkylation / 3.1: Oxidation / 4.1: Cyclization / 5.1: Ring cleavage / 5.2: Cyclization / 6.1: Addition / 7.1: Addition / 8.1: Cyclization / 8.2: Hydrolysis;
DOI:10.1016/S0040-4039(99)01322-2

Reference yield:

: 95514-03-7
(R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate

: 251353-57-8
(S)-5-[(1R,2R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: DIBAH / diethyl ether / -78 °C

2.1: diethyl ether

3.1: NaH; n-BuI / tetrahydrofuran

4.1: OsO₄; NMO / H₂O; acetone

5.1: PPTS / CH₂Cl₂

6.1: CH₂Cl₂

6.2: K₂CO₃ / methanol

7.1: n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 °C

8.1: HgCl₂

9.1: K₂CO₃ / methanol

9.2: 3M HCl

With osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; 1-iodo-butane; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; mercury dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; 1.1: Reduction / 2.1: Addition / 3.1: Alkylation / 4.1: Oxidation / 5.1: Cyclization / 6.1: Ring cleavage / 6.2: Cyclization / 7.1: Addition / 8.1: Addition / 9.1: Cyclization / 9.2: Hydrolysis;
DOI:10.1016/S0040-4039(99)01322-2