Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

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Chemical Name:Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester
CAS No.:251353-62-5
Molecular Formula:C₅₄H₆₈O₁₀
Molecular Weight:877.128
Hs Code.:

Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

Synonyms:Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

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Chemical Property of Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

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Technology Process of Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

There total 16 articles about Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 64-18-6
formic acid

: 251353-72-7
(3R,4R,5S,7R,13R,14S,16S)-4,13,14,16-Tetrakis-benzyloxy-3,7-dimethyl-17-(tetrahydro-pyran-2-yloxy)-heptadec-9-yne-5,8-diol

: 251353-62-5
Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

Guidance literature:: With pyridine; acetic anhydride;
DOI:10.1016/S0040-4039(99)01322-2

Reference yield:

: (2S,3R)-3-Benzyloxy-2-methyl-3-((S)-5-oxo-tetrahydro-furan-2-yl)-propionaldehyde

: 251353-62-5
Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: n-BuLi / tetrahydrofuran

2: H₂ / Pd-C / ethyl acetate

3: TfOH / CH₂Cl₂; cyclohexane

4: 68 percent / LiHMDS / tetrahydrofuran / -78 °C

5: 72 percent / n-BuLi / diethyl ether / -20 °C

6: 85 percent / NaBH₄; CeCl₃ / methanol

7: 97 percent / Ac₂O; Py

With pyridine; sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; trifluorormethanesulfonic acid; hydrogen; acetic anhydride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; ethyl acetate; 1: Condensation / 2: Catalytic hydrogenation / 3: Etherification / 4: Alkylation / 5: Acylation / 6: Reduction / 7: Esterification;
DOI:10.1016/S0040-4039(99)01322-2

Reference yield:

: 251353-68-1
(S)-5-((1R,2R)-1-Benzyloxy-3-hydroxy-2-methyl-propyl)-dihydro-furan-2-one

: 251353-62-5
Formic acid (6R,7S,9S)-6,7,9-tris-benzyloxy-1-((1R,3S,4R,5R)-4-benzyloxy-3-formyloxy-1,5-dimethyl-heptyl)-10-(tetrahydro-pyran-2-yloxy)-dec-2-ynyl ester

Guidance literature:: Multi-step reaction with 8 steps

2: n-BuLi / tetrahydrofuran

3: H₂ / Pd-C / ethyl acetate

4: TfOH / CH₂Cl₂; cyclohexane

5: 68 percent / LiHMDS / tetrahydrofuran / -78 °C

6: 72 percent / n-BuLi / diethyl ether / -20 °C

7: 85 percent / NaBH₄; CeCl₃ / methanol

8: 97 percent / Ac₂O; Py

With pyridine; sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; trifluorormethanesulfonic acid; hydrogen; acetic anhydride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; ethyl acetate; 1: Oxidation / 2: Condensation / 3: Catalytic hydrogenation / 4: Etherification / 5: Alkylation / 6: Acylation / 7: Reduction / 8: Esterification;
DOI:10.1016/S0040-4039(99)01322-2