2-Amino-4,5-dichlorobenzothiazole

Base Information

• Chemical Name: 2-Amino-4,5-dichlorobenzothiazole
• CAS No.: 1849-71-4
• Molecular Formula: C7H4 Cl2 N2 S
• Molecular Weight: 219.09
• Hs Code.: 29342000
• DSSTox Substance ID: DTXSID80349883
• Wikidata: Q82125420
• Mol file: 1849-71-4.mol

Synonyms:1849-71-4;4,5-dichloro-1,3-benzothiazol-2-amine;2-amino-4,5-dichlorobenzothiazole;4,5-Dichloro-benzothiazol-2-ylamine;4,5-Dichlorobenzo[d]thiazol-2-amine;2-Amino-4,5-dichlorobenzothiazole.;MFCD02093913;BAS 07776396;SCHEMBL6234259;DTXSID80349883;GMOFXJZIUQGHTF-UHFFFAOYSA-N;4,5-Dichloro-2-Benzothiazolamine;BAA84971;2-Benzothiazolamine, 4,5-dichloro-;STK345722;AKOS000108933;CCG-274993;BS-27413;BB 0245425;FT-0655138;EN300-25775;F14993;4,5-dichloro-benzothiazol-2-ylamine, AldrichCPR;A812912;Z57603637;F1911-0019

Chemical Property of 2-Amino-4,5-dichlorobenzothiazole

Chemical Property:

• Vapor Pressure: 5.73E-06mmHg at 25°C
• Refractive Index: 1.761
• Boiling Point: 379.7°Cat760mmHg
• Flash Point: 183.5°C
• PSA: 67.15000
• Density: 1.654g/cm³
• LogP: 3.76650
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 217.9472247
• Heavy Atom Count: 12
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

4,5-Dichloro-1,3-benzothiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C2=C1SC(=N2)N)Cl)Cl

Technology Process of 2-Amino-4,5-dichlorobenzothiazole

There total 4 articles about 2-Amino-4,5-dichlorobenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

potassium thioacyanate (333-20-0) + 2,3-dichloroaniline (608-27-5) → 4,5-dichloro-1,3-benzothiazol-2-amine (1849-71-4)

Guidance literature:

With sodium iodide dichloride; at 70 ℃; for 0.5h;

DOI:10.1055/s-0032-1317080

Reference yield:

2,3-dichloroaniline (608-27-5) → 4,5-dichloro-1,3-benzothiazol-2-amine (1849-71-4)

Guidance literature:

With sodium hydroxide; bromine; In acetic acid;

Reference yield:

1-(2,3-dichlorophenyl)thiourea (41542-06-7) → 4,5-dichloro-1,3-benzothiazol-2-amine (1849-71-4)

Guidance literature:

(2,3-dichlorophenyl)thiourea; With bromine; In chloroform; at 5 ℃; Reflux;

With ammonia; In water;

DOI:10.1007/s11164-010-0211-9

upstream raw materials:

2,3-dichloroaniline

1-(2,3-dichlorophenyl)thiourea

potassium thioacyanate

Downstream raw materials:

2-amino-3,4-dichlorobenzenethiol

6,7-dichloro-4-phenyl-2H-pyrimido[2,1-b]benzothiazol-2-one

3-(4′,5′-dichlorobenzothiazol-2-yl)-2-(4′-chlorostyryl)quinazolin-4(3H)-one

3-(4′,5′-dichlorobenzothiazol-2-yl)-2-(4′-methoxystyryl)quinazolin-4(3H)-one

Refernces

• 1、 Sharma, Praveen Kumar,Kumar,Mohan, Vimal. "Synthesis and antimicrobial activity of 2H-pyrimido[2,1-b]benzothiazol-2- ones". . p. 985 - 993. Retrieved 2012/01/05.