Technology Process of (+)(R) methyl 3,5-dimethoxy-6-<8-oxo-9-(p-tolylsulfinyl) nonyl> benzoate
There total 12 articles about (+)(R) methyl 3,5-dimethoxy-6-<8-oxo-9-(p-tolylsulfinyl) nonyl> benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: conc. H2SO4 / 2 h / Ambient temperature
2: 80 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature
3: NaI, NaHCO3 / acetone / 72 h / Ambient temperature
4: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) 5 min
5: 98 percent / Na2HPO4, 6percent sodium amalgam / methanol / 1 h / -20 °C
6: 1.) LDA / 1.) THF, -30 deg C, 0.5 h, 2.) -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium amalgam; sulfuric acid; sodium hydrogencarbonate; triethylamine; sodium iodide; lithium diisopropyl amide;
In
methanol; dichloromethane; acetone;
DOI:10.1016/0957-4166(90)90013-Z
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) 5 min
2: 94 percent / m-chloroperbenzoic acid (m-CPBA) / CH2Cl2 / 1 h / Ambient temperature
3: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) 5 min
4: 98 percent / Na2HPO4, 6percent sodium amalgam / methanol / 1 h / -20 °C
5: 1.) LDA / 1.) THF, -30 deg C, 0.5 h, 2.) -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium amalgam; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
methanol; dichloromethane;
DOI:10.1016/0957-4166(90)90013-Z
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) 5 min
2: 98 percent / Na2HPO4, 6percent sodium amalgam / methanol / 1 h / -20 °C
3: 1.) LDA / 1.) THF, -30 deg C, 0.5 h, 2.) -78 deg C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium amalgam; lithium diisopropyl amide;
In
methanol;
DOI:10.1016/0957-4166(90)90013-Z
