5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

Base Information

Chemical Name:5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one
CAS No.:444661-91-0
Molecular Formula:C₂₅H₂₃Cl₃N₄O
Molecular Weight:501.843
Hs Code.:

Synonyms:5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

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Chemical Property of 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

Chemical Property:

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Technology Process of 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

There total 20 articles about 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444665-71-8
tert-butyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]amino}piperidine-1-carboxylate

: (0.1% trifluoroacetic acid)-CH3CN

: 444661-91-0
5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: In water; trifluoroacetic acid;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 444661-91-0
5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: aq. Na₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 100 °C

2: H₂ / Pd/C / ethyl acetate

3: NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

4: TFA / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In ethanol; ethyl acetate; 1,2-dichloro-ethane; toluene; 1: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

: 101581-06-0
1,3-dibromo-2-methyl-5-nitrobenzene

: 444661-91-0
5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: NBS; AIBN; (BzO)2 / CCl₄

2: K₂CO₃ / dimethylformamide

3: CH₂Cl₂

4: CuI; iPr₂NEt / dimethylformamide / 130 °C

5: aq. Na₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 100 °C

6: H₂ / Pd/C / ethyl acetate

7: NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

8: TFA / Heating

With N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrachloromethane; ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 4: Ullmann cyclization / 5: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00990-3