4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

Base Information

Chemical Name:4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine
CAS No.:1433359-02-4
Molecular Formula:C₂₀H₂₆N₆O₂
Molecular Weight:382.465
Hs Code.:

Synonyms:4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

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Chemical Property of 4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

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Technology Process of 4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

There total 6 articles about 4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1433363-10-0
5-tert-butyl-7-chloro-3-(4-methoxy benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

: 1433359-02-4
4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1433359-02-4
4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / acetonitrile / 5 h / Inert atmosphere; Reflux

2.1: sodium ethanolate / ethanol / 21 h / Inert atmosphere; Reflux

3.1: pyridine / 2 h / 80 °C / Inert atmosphere

3.2: 1 h / 80 °C / Inert atmosphere

3.3: 18 h / Reflux

4.1: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux; Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With pyridine; sodium azide; sodium ethanolate; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; trichlorophosphate; In ethanol; acetonitrile;

Reference yield:

: 133992-53-7
5-amino-1-[(4-methoxyphenyl)methyl]-1,2,3-triazole-4-carboxamide

: 1433359-02-4
4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 2 h / 80 °C / Inert atmosphere

1.2: 1 h / 80 °C / Inert atmosphere

1.3: 18 h / Reflux

2.1: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux; Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; trichlorophosphate; In acetonitrile;