ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

Base Information

Chemical Name:ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate
CAS No.:1427330-88-8
Molecular Formula:C₂₃H₁₉F₄NO₃
Molecular Weight:433.402
Hs Code.:

Synonyms:ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

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Chemical Property of ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

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Technology Process of ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

There total 7 articles about ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.2%

: 1427330-96-8
ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)benzoyl]amino]phenoxy]acetate

: 1427330-88-8
ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

Guidance literature:: With diborane; In tetrahydrofuran; at 0 - 60 ℃; for 2h;

Reference yield:

: 1178958-75-2
2-fluoro-5-(3-fluorophenyl)benzoic acid

: 1427330-88-8
ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / 65 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 20 °C

3: borane-THF / tetrahydrofuran / 2 h / 0 - 60 °C

With thionyl chloride; borane-THF; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 146328-85-0
5-bromo-2-fluoro-benzoic acid

: 1427330-88-8
ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl amino]phenoxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: thionyl chloride / 1 h / 65 °C / Inert atmosphere

3: triethylamine / dichloromethane / 3 h / 20 °C

4: borane-THF / tetrahydrofuran / 2 h / 0 - 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;