2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

Base Information

Chemical Name:2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione
CAS No.:1264498-87-4
Molecular Formula:C₂₁H₁₃Cl₄NO₃
Molecular Weight:469.151
Hs Code.:

Synonyms:2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

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Chemical Property of 2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

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Technology Process of 2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

There total 4 articles about 2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1264498-77-2
2-(2,2,2-trichloroacetyl)-5,10-dimethoxy-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline

: 1264498-87-4
2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

Guidance literature:: With nitric acid; silver(l) oxide; In 1,4-dioxane; at 50 ℃; for 16h;
DOI:10.1039/c0ob00391c

Reference yield:

: 1264498-72-7
N-(4-chlorobenzylidene)-2-(1,4-dimethoxynaphthalen-2-yl)ethanamine

: 1264498-87-4
2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium iodide / 1,2-dichloro-ethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

1.2: 3 h / Reflux; Inert atmosphere

2.1: nitric acid; silver(l) oxide / 1,4-dioxane / 16 h / 50 °C

With nitric acid; potassium iodide; silver(l) oxide; In 1,4-dioxane; 1,2-dichloro-ethane; 1.1: Pictet-Spengler cyclisation / 1.2: Pictet-Spengler cyclisation;
DOI:10.1039/c0ob00391c

Reference yield:

: 207740-21-4
2-(1,4-dimethoxynaphth-2-yl)ethylamine

: 1264498-87-4
2-(2,2,2-trichloroacetyl)-1-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[g]isoquinoline-5,10-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium sulfate / dichloromethane / 4 h / Reflux

2.1: potassium iodide / 1,2-dichloro-ethane / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 3 h / Reflux; Inert atmosphere

3.1: nitric acid; silver(l) oxide / 1,4-dioxane / 16 h / 50 °C

With nitric acid; magnesium sulfate; potassium iodide; silver(l) oxide; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; 2.1: Pictet-Spengler cyclisation / 2.2: Pictet-Spengler cyclisation;
DOI:10.1039/c0ob00391c