8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene

Base Information

• Chemical Name: 8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene
• CAS No.: 72035-78-0
• Molecular Formula: C₂₁H₂₂O
• Molecular Weight: 290.405
• Mol file: 72035-78-0.mol

Synonyms:8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene

Chemical Property of 8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene

There total 2 articles about 8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2-Dimethyl-3-phenyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol (72035-61-1) + methyl iodide (74-88-4) → 8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene (72035-78-0)

Guidance literature:

With sodium hydride; In diethyl ether; for 5h; Heating;

DOI:10.1021/jo01290a007

Reference yield:

5,5-dimethyl-3-phenyl-2-cyclohexen-1-one (36047-17-3) → 8b-Methoxy-2,2-dimethyl-3-phenyl-1,2,2a,8b-tetrahydro-cyclobuta[a]naphthalene (72035-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / NaNH₂, t-BuOH / tetrahydrofuran / 4 h

2: 90 percent / NaH / diethyl ether / 5 h / Heating

With sodium hydride; sodium amide; tert-butyl alcohol; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo01290a007

upstream raw materials:

2,2-Dimethyl-3-phenyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

methyl iodide

5,5-dimethyl-3-phenyl-2-cyclohexen-1-one