N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

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Chemical Name:N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide
CAS No.:1430724-18-7
Molecular Formula:C₂₂H₂₀N₆O₂S
Molecular Weight:432.506
Hs Code.:

Synonyms:N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

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Chemical Property of N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

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Technology Process of N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

There total 10 articles about N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1430727-93-7
3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)aniline

: 124-63-0
methanesulfonyl chloride

: 1430724-18-7
N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 321329-77-5
1-(3,5-dinitro-phenyl)-1H-pyrrole

: 1430724-18-7
N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: diammonium sulfide; pyridine / water; ethanol / 4 h / 80 °C

2: 0.5 h / 20 °C

3: water; calcium chloride; iron / ethanol / 2 h / 80 °C

4: potassium fluoride / N,N-dimethyl-formamide / 110 °C

5: water; calcium chloride; iron / ethanol / 2 h / 80 °C

6: 2 h / 20 - 100 °C

7: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 2 h / 100 °C / Inert atmosphere

8: sodium hydroxide / ethanol / 2 h / 100 °C

9: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; diammonium sulfide; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iron; sodium carbonate; calcium chloride; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 618-87-1
3, 5-dinitroaniline

: 1430724-18-7
N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid / 16 h / 100 °C

2: diammonium sulfide; pyridine / water; ethanol / 4 h / 80 °C

3: 0.5 h / 20 °C

4: water; calcium chloride; iron / ethanol / 2 h / 80 °C

5: potassium fluoride / N,N-dimethyl-formamide / 110 °C

6: water; calcium chloride; iron / ethanol / 2 h / 80 °C

7: 2 h / 20 - 100 °C

8: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 2 h / 100 °C / Inert atmosphere

9: sodium hydroxide / ethanol / 2 h / 100 °C

10: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; diammonium sulfide; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iron; sodium carbonate; acetic acid; calcium chloride; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;