(4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

Base Information

Chemical Name:(4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone
CAS No.:311771-02-5
Molecular Formula:C₃₁H₃₁F₃N₂O₅
Molecular Weight:568.593
Hs Code.:

Synonyms:(4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

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Chemical Property of (4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

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Technology Process of (4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

There total 5 articles about (4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 311771-00-3
(4S)-3-[3-(3-carboxy-4-methoxyphenyl)-2-ethylpropionyl]-4-benzyl-2-oxazolidinone

: 3300-51-4
p-Trifluoromethylbenzylamine

: 311771-02-5
(4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

Guidance literature:: (4S)-3-[3-(3-carboxy-4-methoxyphenyl)-2-ethylpropionyl]-4-benzyl-2-oxazolidinone; With chloroformic acid ethyl ester; triethylamine; In dichloromethane;

p-Trifluoromethylbenzylamine; In dichloromethane;

Reference yield:

: (4S)-3-[3-(3-benzyloxycarbonyl-4-methoxyphenyl)-2-ethyl-3-hydroxypropionyl]-4-benzyl-2-oxazolidinone

: 311771-02-5
(4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; trifluoroacetic acid / 98.4 h / 0 - 20 °C

2: chloroformic acid ethyl ester; triethylamine / dichloromethane

With triethylsilane; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 84923-70-6
5-formyl-2-methoxybenzoic acid

: 311771-02-5
(4S)-3-[2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]-carbamoyl]phenyl]propionyl]-4-benzyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane / 1.58 h / -74 - 0 °C

2.2: 3.83 h / -75 - 0 °C

2.3: phosphate buffer / 0.5 h / 0 °C

3.1: triethylsilane; trifluoroacetic acid / 98.4 h / 0 - 20 °C

4.1: chloroformic acid ethyl ester; triethylamine / dichloromethane

With triethylsilane; di-n-butylboryl trifluoromethanesulfonate; chloroformic acid ethyl ester; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;