Technology Process of methyl 3-bromo-5-(3-fluorobenzyl)-4-methylbenzoate
There total 4 articles about methyl 3-bromo-5-(3-fluorobenzyl)-4-methylbenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
bromo(3-fluorophenyl)magnesium;
With
copper(l) cyanide;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 0.75h;
methyl 3-bromo-5-(iodomethyl)-4-methylbenzoate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 20.6667h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / trans-dichlorobis(triphenylphosphine)palladium(II) / water; N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere of nitrogen
2.1: ozone / dichloromethane / -78 °C
2.2: 6 h / -78 - 20 °C / Inert atmosphere of nitrogen
3.1: sodium tetrahydroborate / methanol / 3 h / 20 °C
4.1: 1H-imidazole; triphenylphosphine-iodine complex / dichloromethane / 0.5 h / 20 °C
5.1: copper(l) cyanide / tetrahydrofuran / 0.75 h / -78 - 0 °C
5.2: 20.67 h / -78 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; copper(l) cyanide; sodium carbonate; ozone; triphenylphosphine-iodine complex;
trans-dichlorobis(triphenylphosphine)palladium(II);
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
1.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / methanol / 3 h / 20 °C
2.1: 1H-imidazole; triphenylphosphine-iodine complex / dichloromethane / 0.5 h / 20 °C
3.1: copper(l) cyanide / tetrahydrofuran / 0.75 h / -78 - 0 °C
3.2: 20.67 h / -78 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; copper(l) cyanide; triphenylphosphine-iodine complex;
In
tetrahydrofuran; methanol; dichloromethane;
