{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

Base Information

Chemical Name:{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane
CAS No.:568572-02-1
Molecular Formula:C₅₀H₆₆O₉Si
Molecular Weight:839.154
Hs Code.:

{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

Synonyms:{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

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Chemical Property of {(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

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Technology Process of {(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

There total 20 articles about {(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 568571-89-1
(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

: 568572-02-1
{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/ja042686r

Reference yield:

: 568571-87-9
(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

: 568572-02-1
{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-BBN / tetrahydrofuran / 2.5 h / 20 °C

1.2: 9.46 g / Pd(PPh₃)4; aq. NaHCO₃ / dimethylformamide; tetrahydrofuran / 14 h / 50 °C

2.1: BH₃*SMe₂ / tetrahydrofuran / 4 h / 0 °C

2.2: 2.98 g / aq. H₂O₂; NaOH / tetrahydrofuran / 2.5 h / 20 °C

3.1: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

With 2,6-dimethylpyridine; 9-borabicyclo[3.3.1]nonane dimer; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane; 1.2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ja042686r

Reference yield:

: 568571-86-8
[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-yl]-methanol

: 568572-02-1
{(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy}-triethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / I₂; imidazole; PPh₃ / benzene / 0.58 h / 20 °C

2.1: 95 percent / potassium t-butoxide / tetrahydrofuran / 1.5 h / 0 °C

3.1: 9-BBN / tetrahydrofuran / 2.5 h / 20 °C

3.2: 9.46 g / Pd(PPh₃)4; aq. NaHCO₃ / dimethylformamide; tetrahydrofuran / 14 h / 50 °C

4.1: BH₃*SMe₂ / tetrahydrofuran / 4 h / 0 °C

4.2: 2.98 g / aq. H₂O₂; NaOH / tetrahydrofuran / 2.5 h / 20 °C

5.1: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; 9-borabicyclo[3.3.1]nonane dimer; dimethylsulfide borane complex; potassium tert-butylate; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane; benzene; 3.2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ja042686r