tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate
• CAS No.: 1622003-39-7
• Molecular Formula: C₁₆H₂₃N₃O₆
• Molecular Weight: 353.375
• Mol file: 1622003-39-7.mol

Synonyms:tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate

Chemical Property of tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate

There total 1 articles about tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-tert-butoxycarbonyl-3-aminopropanol (58885-58-8) + 2-fluoro-4-methyl-5-nitrobenzamide (1622004-11-8) → tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate (1622003-39-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; for 0.583333h;

Reference yield: 100.0%

tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate (1622003-39-7) → tert-butyl (3-(4-amino-2-carbamoyl-5-methylphenoxy)propyl)carbamate (1622003-40-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h;

Reference yield:

tert-butyl (3-(2-carbamoyl-5-methyl-4-nitrophenoxy)propyl)carbamate (1622003-39-7) → C24H26ClN7O3 (1622003-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: sodium carbonate; tert-Amyl alcohol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / water / 2 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.25 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-Amyl alcohol; palladium 10% on activated carbon; hydrogen; sodium carbonate; trifluoroacetic acid; DavePhos; In methanol; dichloromethane; water;

upstream raw materials:

N-tert-butoxycarbonyl-3-aminopropanol

2-fluoro-4-methyl-5-nitrobenzamide

Downstream raw materials:

tert-butyl (3-(4-amino-2-carbamoyl-5-methylphenoxy)propyl)carbamate

C₂₄H₂₆ClN₇O₃

tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate

N¹-(3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)-N⁵-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide